The GPR44 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The GPR44 Antibody has been validated for the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Description: Orphan receptor.
Function: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca2+ mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
Post-translational Modifications: Phosphorylated.
Similarity: The 330-DSEL-333 motif is involved in the recycling of PTGDR2 to the cell surface after agonist-induced internalization. This motif seems to be required for GRK2 and GPRK5/GRK5 to promote agonist-induced internalization. Thr-347 is a major site for PKC-induced internalization of the receptor. Belongs to the G-protein coupled receptor 1 family